|
KMID : 0043319950180040267
|
|
Archives of Pharmacal Research
1995 Volume.18 No. 4 p.267 ~ p.270
|
|
|
Effects of Chronic Dextromethorphan Administration on the Cellular Immune Responses in Mice
|
|
Kim Hyoung-Chun
Jhoo Wang-Kee
Kwan Myung-Sang
Hong Jau-Shyong
|
|
|
Abstract
|
|
|
|
We examined the chronic effect of dextromethorphan(DM) on the cellular immune responses in mice. T cell simulator, phytohemagglutinin did not show singificant effect on lymphocyte proliferation. Costimulator of T and B cell, pokeweed mitogen, and B cell stimulator, lipopolysaccharide exhibited DM-induced decreased lymphocyte proliferation. Singificantly suppressed natural killer (NR) cell cytotoxicity was evidenced following 6 months DM exposure. These results suggest that chronic DM administration pertub B cell functioning and NK cell cytotoxicity. In addition, prenatal DM exposure did not potentiate the immunomodulation in postnatal effect induced by chronic DM.
|
|
|
KEYWORD
|
|
|
Chronic dextromethorphan, Cellular immune responses
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|